Safety of a silicone elastomer vaginal ring as potential microbicide delivery method in African women: A Phase 1 randomized trial.

Women in sub-Saharan Africa are in urgent need of female-initiated human immunodeficiency virus (HIV) preventative methods.Vaginal rings are one dosage form in development for delivery of HIV microbicides.However, African women have read more limited experience with vaginal rings.This Phase I, randomized, crossover trial assessed and compared the s

read more

The protocadherins, PCDHB1 and PCDH7, are regulated by MeCP2 in neuronal cells and brain tissues: implication for pathogenesis of Rett syndrome

Abstract Background Rett syndrome is a neurodevelopmental and autistic disease caused by mutations of life extension blueberry extract Methyl-CpG-binding protein 2 (MECP2) gene.MeCP2 protein is mainly expressed in neurons and binds to methylated gene promoters to suppress their expression, indicating that Rett syndrome is caused by the deregulation

read more